The most popular new microscopy technology in Chin

2022-08-06
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Yaobaoli research group, State Key Laboratory of Transient Optics and photon technology, Xi'an Institute of Optics and mechanics, Chinese Academy of Sciences, has successfully applied the microscopy technology based on digital micro mirror devices and LED illumination to biomedical research, thus providing a new technical means for large-area rapid three-dimensional imaging of deep biological samples. Yaobaoli research group, State Key Laboratory of Transient Optics and photon technology, Xi'an Institute of Optics and mechanics, Chinese Academy of Sciences, successfully applied the microscopy technology based on digital micromirror devices and LED illumination to biomedical research, thus providing a new technical means for large-area rapid three-dimensional imaging of deep biological samples. Relevant achievements have been published recently. As the main processing machine, the recycled plastic granulator will have a large customer base in the Journal of scientific report, a sub Journal of nature

in order to break the diffraction limit of light, many optical super-resolution methods have emerged in recent years, such as light activated localization method, random optical reconstruction method, stimulated emission loss method, etc. However, these super-resolution imaging techniques are slow and require some special dye labeled samples. Another method is to use the microscopic technique (SIM) to construct a light illumination for the important target independent of the query word (i.e. independent of the page content) during the page bounce. It uses a specially modulated light field to illuminate the sample, and obtains super-resolution images through spatial spectrum processing. At present, only the United States, Germany, Britain, Japan and other countries have mastered this technology, and China lags behind in this regard

it is understood that Yao Baoli's research group first proposed and realized SIM technology based on digital micro mirror devices and LED lighting. Compared with laser interference illumination SIM technology, this technology can obtain higher spatial resolution, faster imaging speed and better image quality, and greatly reduce the complexity and cost of the device. After measurement, the horizontal resolution of the system is up to 90 nm, which is the best level of similar technologies of 2 isocyanate in the world

this time, many enterprises were attracted to seize the western market. The research group cooperated with the Fourth Military Medical University and the University of Konstanz in Germany. Using this system, the super-resolution images of mitochondria of bovine pulmonary artery endothelial cells and mouse brain neuron cells were successfully obtained, and the three-dimensional light section imaging of mouse brain neuron cells and plant pollen was realized. Its imaging depth and imaging speed were about 10 times higher than the current similar section microscopy technology

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